Cart
sales@molnova.com
Raphin1 acetate
CAS No. 2242616-04-0
Raphin1 acetate( —— )
Catalog No. M22087 CAS No. 2242616-04-0
Raphin1 acetate is a selective and orally bioavailable regulatory phosphatase PPP1R15B (R15B) inhibitor.Raphin1, a selective inhibitor of R15B.?In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 63 | In Stock |
|
| 10MG | 99 | In Stock |
|
| 25MG | 186 | In Stock |
|
| 50MG | 320 | In Stock |
|
| 100MG | 476 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameRaphin1 acetate
-
NoteResearch use only, not for human use.
-
Brief DescriptionRaphin1 acetate is a selective and orally bioavailable regulatory phosphatase PPP1R15B (R15B) inhibitor.Raphin1, a selective inhibitor of R15B.?In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.?
-
DescriptionRaphin1 acetate is a selective and orally bioavailable regulatory phosphatase PPP1R15B (R15B) inhibitor.Raphin1, a selective inhibitor of R15B.?In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.?In vitro, Raphin1 inhibits the recombinant R15B-PP1c holoenzyme, but not the closely related R15A-PP1c, by interfering with substrate recruitment.Raphin1 was orally bioavailable, crossed the blood-brain barrier, and demonstrated efficacy in a mouse model of Huntington's disease.?
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayMetabolic Enzyme/Protease
-
TargetPhosphatase
-
Recptorphosphatase?PPP1R15B (R15B)
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2242616-04-0
-
Formula Weight291.13
-
Molecular FormulaC10H12Cl2N4O2
-
Purity>98% (HPLC)
-
SolubilityDMSO:40 mg/mL?(137.4 mM;?Need ultrasonic)
-
SMILESCC(O)=O.NC(=N)N\N=C\c1cccc(Cl)c1Cl
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Krzyzosiak A, et al. Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. Cell. 2018 Aug 23;174(5):1216-1228.e19.
molnova catalog
related products
-
SHIP2-IN-1
SHIP2-IN-1 is a potent SHIP2 inhibitor(IC50 : 2 μM),and used in the research of Alzheimer’s disease.
-
Managlinat dialaneti...
Managlinat dialanetil (MB06322) is an orally available and potent fructose 1,6-bisphosphatase (FBPase) inhibitor with hypoglycaemic activity for the study of type 2 diabetes.
-
MLS000544460
MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor (Kd: 2.0 μM, IC50: 4 μM) that exhibits inhibitory effects on Eya2 phosphatase-mediated cell migration and has anticancer activity.
